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. 2007 Jun 8;3(6):e82. doi: 10.1371/journal.ppat.0030082

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© 2007 Nentwig et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Comparison of PrP^sc immunolabeling with monoclonal antibody F99/97.6.1 in IHC (upper panel) and vacuolar lesion in histopathology (lower panel) in atypical scrapie cases S6/FS (A) and S7/CS (B) in sheep, compared to a classical scrapie reference case from Switzerland (C) in different neuroanatomical brain structures: brainstem, spinal tract nucleus of the trigeminal nerve (STNT); cerebellar cortex (CC), and basal ganglia (BG).

(B) The inset for S7/CS, basal ganglia, shows plaque-like PrP^sc deposits in the ventral and the medial geniculate body of the thalamus. Bars indicate 100 μm, except for the IHC of CC (150 μm).