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. 2007 Feb 1;25(4):1097–1111. doi: 10.1111/j.1460-9568.2007.05344.x

Fig. 9.

Fig. 9

Effects of the anti-cell adhesion molecule L1 (L1-CAM) antibody on sciatic nerve transection (SCNT)-induced alteration of L1-CAM and phosphorylation of MAPKs in the dorsal root ganglia (DRGs). Photomicrographs show the expression of L1-CAM-immunoreactive (ir) ring structure (A–C), phosphorylated p38-ir profiles (E–G) and phosphorylated extracellular signal-regulated kinase (p-ERK)-ir profiles (I–K). Tissue sections are L5 DRGs of a control naive rat (A, E and I), 7 days after SCNT treatment with intrathecal control IgG (B, F and J) and 7 days after SCNT treatment with intrathecal chronic injection of anti-L1-CAM antibody (600 ng/day) (C, G and K). Quantification of the percentage of neurons with L1-CAM-ir ring structures (D), phospho-p38 MAPK (p-p38)-ir neurons (H) and p-ERK-ir neurons (L) at 7 days after SCNT (mean ± SEM; n = 4, more than 500 total neurons from each rat) (Ab, antibody). P < 0.05 compared with saline-treated group (anova); NS, not significant (P > 0.05); #P < 0.05 (anova) compared with naive control. Scale bars: A–C and E–G, 50 µm; I–K, 100 µm.