TABLE 3.

Competitive inhibition constant K_i of 2-picolinic acid and its derivatives for CphA and the N116H-N220G double mutant^a

Inhibitor	Ki (μM)
	Wild type	N116H-N220G mutant
2,3-PDCA	200 ± 20	ND
2,4-PDCA	4.5 ± 0.5	28 ± 4 (35 ± 5)
2,5-PDCA	420 ± 10	ND
3,4-PDCA	1,100 ± 40	ND
2-Picolinic acid	5.7 ± 0.9	13 ± 2 (NA)

^aK_i values were found using 100 μM imipenem. Values are means ± standard deviations. The data shown in parentheses are those obtained with the dizinc form. ND, not determined; NA, not applicable (see text).