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pH dependence of the Ki values for 2,4-PDCA and 2-picolinic acid with CphA by using imipenem as the reporter substrate at a final concentration of 100 μM
| Inhibitor |
Ki (μM) at pHa:
|
|||
|---|---|---|---|---|
| 7.0 | 8.0 | 9.0 | 10.0 | |
| 2,4-PDCA | 17 ± 1 | 35 ± 1 | 160 ± 10 | 520 ± 50 |
| 2-Picolinic acid | 46 ± 2 | 76 ± 1 | 440 ± 40 | 1,100 ± 80 |
Values are means ± standard deviations.
