TABLE 3.
Detection of M414T mutant from 1b replicon cell lines and HCV subtype 1b-infected subjects
| Replicon or subject no. | Sample | Mean %M414Ta ± SD |
|---|---|---|
| Replicon | 1b-conl | 0.22 ± 0.04 |
| 1b-N | 0.18 ± 0.05 | |
| Subject no. | 0712 | <0.1 |
| 1025 | <0.1 | |
| 1182 | <0.1 | |
| 1694 | 0.17 ± 0.05 | |
| 1934 | 0.19 ± 0.06 | |
| 4374 | 0.11 ± 0.04 | |
| 4376 | 0.60 ± 0.17 | |
| 4377 | 0.23 ± 0.06 | |
| 4393 | <0.1 | |
| 4409 | <0.1 | |
| 4410 | <0.1 | |
| 4411 | <0.1 | |
| 4413 | 0.12 ± 0.04 | |
| 4428 | <0.1 | |
| 4430 | <0.1 |
a
The %M414T = 100 × M414T copies/(M414T copies + wild-type copies). Data are shown as the means from three different experiments. The limit of detection of the M414T mutant is >0.1% in the population.