TABLE 3.
MICs of various compounds against S. aureus rplC mutants
| Alteration(s) in L3 | MIC (μg/ml) ofa:
|
|||||
|---|---|---|---|---|---|---|
| REP | TIA | CM | TC | LEV | MUP | |
| None (wild type) | ≤0.06 | 0.25 | 4 | 0.25 | 0.5 | 0.06 |
| D159Y | 0.25 | 4 | 4 | 0.25 | 0.5 | 0.06 |
| G155R | 0.5 | 4 | 8 | 0.25 | 0.5 | 0.06 |
| S158L | 0.25 | 2 | 4 | 0.25 | 0.5 | 0.06 |
| G152D | 0.25 | 4 | 8 | 0.25 | 0.5 | 0.06 |
| G152D D159Y | 1 | 16 | 8 | 0.25 | 0.25 | 0.06 |
| G152D G155R | 1 | 16 | 8 | 0.25 | 0.25 | 0.06 |
| G152D D159Y G144R | 4 | 32 | 8 | 0.25 | 0.25 | 0.06 |
| G152D D159Y G155R | 4 | >64 | 4 | 0.25 | 0.25 | 0.06 |
| G152D D159Y G155R H134N | 0.125 | 2 | 8 | 0.25 | 0.5 | 0.06 |
| G152D D159Y G155R A150T | 0.25 | 4 | 8 | 0.25 | 0.125 | 0.06 |
a
Abreviations: REP, retapamulin; TIA, tiamulin; CM, chloramphenicol; TC, tetracycline; LEV, levofloxacin; MUP, mupirocin.