TABLE 2.
Pharmacokinetic data for SQV in plasma and cellular compartmenta
| SQV | Median and CV pharmacokinetic data
|
|||||||
|---|---|---|---|---|---|---|---|---|
|
Cmax
|
Cmin
|
AUC0-24
|
t1/2 β
|
|||||
| ng/ml (range) | CV (%) | ng/ml (range) | CV (%) | ng·h/ml (range) | CV (%) | h (range) | CV (%) | |
| Plasma | ||||||||
| n = 26 | 3,672 (999-9,832) | 49.7 | 431 (62-848) | 60.7 | 34,283 (12,645-70,389) | 42.3 | 8.25 (2.4-20.7) | 49.1 |
| n = 102 | 350 (62-1,119) | 65.2 | ||||||
| Intracellular | ||||||||
| n = 26 | 10,105 (2,212-19,946) | 48.6 | 996 (401-5,730) | 90.0 | 99,535 (26,595-283,824) | 57.0 | 12.5 (3.5-37) | 62.9 |
| n = 102 | 1,060 (358-6,714) | 87.4 | ||||||
| Ic/P ratio | ||||||||
| n = 26 | 2.75 (0.98-7.15) | 57.5 | 2.39 (0.5-24) | 124.6 | 2.75 (0.9-6.7) | 52.5 | 1.5 (0.5-6.5) | 98.0 |
| n = 102 | 3.01 (0.5-24) | 93.3 | ||||||
a
A 24-h pharmacokinetic profile was obtained from each of 26 patients, and only trough levels were obtained from 72 additional patients. The Ic/P is the ratio of the intracellular to the plasma concentration. CV, coefficient of variation. n, No. of patients.