TABLE 3.
Pharmacokinetic data for SQV in plasma and cellular compartments for the three patients with virological failure in whom a complete 24-h profile was available (n = 3)a
| SQV | Median (range)
|
|||
|---|---|---|---|---|
| Cmax (ng/ml) | Cmin (ng/ml) | AUC0-24 (ng·h/ml) | t1/2 β (h) | |
| Plasma | 3,320 (2,840-3,511) | 383.95 (154-848) | 35,308 (25,254-25,254) | 8.51 (4.9-17.3) |
| Intracellular | 15,198.50 (14,016-16,381) | 1,217.30 (606-5,730) | 132,158.00 (116,478-147,838) | 10.909 (6.3-15.6) |
| Ic/P ratio | 4.46 (3.99-4.93) | 3.014 (1.4-10.1) | 3.53 (3.3-3.8) | 1.5 (0.5-6.5) |
a
The Ic/P ratio is the ratio of the intracellular to the plasma concentration.