TABLE 3.

Differences between the amino acid sequences of the adeR and adeS gene products for the indicated strains^a

Strain	Amino acid at indicated position of protein encoded by indicated gene
	adeR			adeS
	120	142	158	59	60	186	227	245	279	293	327
D54	V	I	H	V	D	G	D	I	A	S	V
A24	I	L	H	V	D	V	D	V	V	G	V
B46	I	L	L	I	D	G	H	V	A	G	E
C75	I	L	L	I	Y	G	H	V	A	G	V
BM4454	I	L	H	V	D	V	D	V	V	G	V

^aThe strains used were a tigecycline-susceptible laboratory strain (D54), a clinical strain (A24), two tigecycline-nonsusceptible clinical strains (B46 and C75), and a previously sequenced Acinetobacter baumannii isolate found to have overexpression of the AdeABC pump (BM4454) (9, 10). V, valine; A, alanine; I, isoleucine; D, aspartic acid; Y, tyrosine; G, glycine; H, histidine; L, leucine; S, serine; and E, glutamic acid.