TABLE 1.
In vitro activity of three investigational compounds in comparison with three established antifungal agents against nine dermatophyte species
| Species (no. of isolates tested) | Compound | MIC (μg/ml)
|
|||
|---|---|---|---|---|---|
| Range | GM | 50%a | 90%b | ||
| T. rubrum (20) | ITC | 0.25-4 | 1.955 | 2 | 4 |
| TRB | 0.008-0.063 | 0.035 | 0.031 | 0.063 | |
| BTF | 0.008-0.125 | 0.050 | 0.063 | 0.125 | |
| MI | 0.25-2 | 0.547 | 0.5 | 1 | |
| PYR | 4-16 | 10.41 | 8 | 16 | |
| AM | 2-8 | 5.876 | 4 | 8 | |
| T. mentagrophytes (18) | ITC | 0.125-4 | 1.682 | 2 | 4 |
| TRB | 0.008-0.5 | 0.030 | 0.031 | 0.063 | |
| BTF | 0.008-1 | 0.063 | 0.063 | 0.125 | |
| MI | 0.25-2 | 1.133 | 1 | 2 | |
| PYR | 2-32 | 9.007 | 8 | 16 | |
| AM | 2-8 | 4.609 | 4 | 8 | |
| T. tonsurans (16) | ITC | 0.25-4 | 1.645 | 2 | 4 |
| TRB | 0.008-0.063 | 0.030 | 0.031 | 0.063 | |
| BTF | 0.008-0.063 | 0.040 | 0.031 | 0.063 | |
| MI | 0.25-1 | 0.398 | 0.25 | 1 | |
| PYR | 1-8 | 2.802 | 2 | 8 | |
| AM | 2-8 | 3.366 | 4 | 4 | |
| T. soudanense (3) | ITC | 1-4 | 3.420 | ||
| TRB | 0.031-0.063 | 0.039 | |||
| BTF | 0.031-0.125 | 0.059 | |||
| MI | 0.25-1 | 0.52 | |||
| PYR | 8-16 | 14.54 | |||
| AM | 4-8 | 6.604 | |||
| T. violaceum (3) | ITC | 2-8 | 3.302 | ||
| TRB | 0.063 | 0.063 | |||
| BTF | 0.063 | 0.063 | |||
| MI | 0.25-0.5 | 0.328 | |||
| PYR | 1-32 | 8.963 | |||
| AM | 2-4 | 2.885 | |||
| All Trichophyton spp. (60) | ITC | 0.125-8 | 1.993 | 2 | 4 |
| TRB | 0.008-0.5 | 0.044 | 0.031 | 0.063 | |
| BTF | 0.008-1 | 0.074 | 0.063 | 0.125 | |
| MI | 0.25-2 | 0.652 | 0.5 | 1 | |
| PYR | 1-32 | 6.981 | 8 | 16 | |
| AM | 2-8 | 4.467 | 4 | 8 | |
| E. floccosum (5) | ITC | 0.063-0.5 | 0.226 | ||
| TRB | 0.031-0.125 | 0.059 | |||
| BTF | 0.063-0.125 | 0.081 | |||
| MI | 0.25-1 | 0.548 | |||
| PYR | 2-16 | 7.635 | |||
| AM | 4-8 | 6.0 | |||
| M. canis (5) | ITC | 0.25-8 | 1.230 | ||
| TRB | 0.031-0.125 | 0.083 | |||
| BTF | 0.063-0.25 | 0.101 | |||
| MI | 0.25-2 | 0.555 | |||
| PYR | 1-4 | 2.954 | |||
| AM | 4 | 4 | |||
| M. gypseum (5) | ITC | 1-8 | 3.680 | ||
| TRB | 0.031-0.125 | 0.065 | |||
| BTF | 0.063-0.25 | 0.084 | |||
| MI | 0.5-1 | 0.842 | |||
| PYR | 1-4 | 2.408 | |||
| AM | 4-8 | 6 | |||
| M. cookei (2) | ITC | 4-8 | 6 | ||
| TRB | 0.063-0.125 | 0.077 | |||
| BTF | 0.125-0.25 | 0.153 | |||
| MI | 0.5-1 | 0.866 | |||
| PYR | 0.5-2 | 1.061 | |||
| AM | 4-16 | 8.485 | |||
| All Microsporum spp. (12) | ITC | 0.25-8 | 2.633 | 4 | 8 |
| TRB | 0.031-0.125 | 0.075 | 0.063 | 0.125 | |
| BTF | 0.063-0.25 | 0.106 | 0.125 | 0.125 | |
| MI | 0.25-2 | 0.750 | 1 | 1 | |
| PYR | 0.5-4 | 2.244 | 2 | 4 | |
| AM | 4-16 | 5.246 | 4 | 8 | |
| All isolates (77) | ITC | 0.063-8 | 1.718 | 2 | 4 |
| TRB | 0.008-0.5 | 0.039 | 0.031 | 0.063 | |
| BTF | 0.008-1 | 0.059 | 0.063 | 0.125 | |
| MI | 0.25-2 | 0.617 | 0.5 | 1 | |
| PYR | 0.5-32 | 6.006 | 8 | 16 | |
| AM | 2-16 | 4.771 | 4 | 8 | |
a
MIC at which 50% of the isolates were inhibited.
b
MIC at which 90% of the isolates were inhibited.