TABLE 4.

Bioactivity of bis-acridine compounds against L. donovani promastigotes

Compound	% Parasite deatha
1	47
2	95
3	96
4	99
5	73
6	98
7	99
8	99
9	46
10	93
11	16
12	49
13	37
14	99
15	99
16	96
17	99
18	42
K11777b	6
Amphotericin B	100

^aParasites were incubated with 10 μM compound for 72 h, and parasite survival was quantified relative to DMSO-treated control cultures.

^bK11777, a peptidomimetic inhibitor of cysteine proteases (12). Each compound was tested three times, and the standard deviations never exceeded 20% of the means.