TABLE 5.
Bioactivities of bis-acridine compounds against 20-day-old S. mansoni parasites
| Compound | Score at concn (μM)a of:
|
||
|---|---|---|---|
| 1 | 3 | 6 | |
| 1 | − | − | − |
| 2 | − | ++ | ++ |
| 3 | − | ++ | ++ |
| 4 | − | ++ | ++ |
| 5 | − | − | ++ |
| 6 | − | + | ++ |
| 7 | − | ++ | ++ |
| 8 | − | − | − |
| 9 | − | − | − |
| 10 | − | − | − |
| 11 | − | − | − |
| 12 | − | − | − |
| 13 | − | − | − |
| 14 | − | − | − |
| 15 | − | − | − |
| 16 | − | − | − |
| 17 | − | + | ++ |
| 18 | − | − | − |
| PZQ | − | + | ++ |
a
Compounds were incubated with parasites at the indicated concentrations. After 4 h, parasite survival was scored visually as follows: −, no effect; +, dying; ++, dead. A second independent experiment yielded identical results.