TABLE 6.
Bioactivities of bis-acridine compounds against T. vaginalis
| Compound | % of parasites that dieda |
|---|---|
| 1 | 0 |
| 2 | 23 |
| 3 | 53 |
| 4 | 75 |
| 5 | 0 |
| 6 | 66 |
| 7 | 92 |
| 8 | 90 |
| 9 | 10 |
| 10 | 80 |
| 11 | 0 |
| 12 | 95 |
| 13 | 53 |
| 14 | 100 |
| 15 | 100 |
| 16 | 75 |
| 17 | 85 |
| 18 | 59 |
| Metronidazole | 100 |
Parasites were incubated for 24 h with compound at 10 μM or metronidazole at 1 μM, and parasite survival was quantified relative to DMSO-treated control cultures. Each compound was tested five times, and the standard deviations never exceeded 15% of the means.