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. 2007 Mar 19;51(6):2240–2243. doi: 10.1128/AAC.01440-06

TABLE 1.

Activities of PMEO-DAPym and selected compounds against wild-type HBV replication and cell viability in Huh7 cells

Compound EC50 (μM)a CC50 (μM)b
Lamivudine 1 ± 1.1 >1,000
Entecavir 0.3 ± 0.42 125 ± 35
Adefovir 13 ± 29 365 ± 120
Tenofovir 16 ± 7.9 >1,000
PMEO-DAPym 4.9 ± 0.6 >1,000
a

For each drug, the EC50 value is the mean of the EC50s for wild-type HBV presented in Tables 2 and 3.

b

CC50s are mean values ± SDs for three independent experiments performed in quadruplicate.