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Effect of AcrAB efflux pump on spermine-dependent antibiotic susceptibility in E. coli
| Antibiotic | MIC (μg/ml)a for indicated strain and treatment
|
|||||
|---|---|---|---|---|---|---|
| W4573 (parent)
|
N43 (acrA)
|
N818 (ΔacrA)
|
||||
| None | SpN | None | SpN | None | SpN | |
| Carbenicillin | 16 | 4 | 4 | 0.25 | 2 | 0.25 |
| Chloramphenicol | 8 | 2 | 2 | <0.06 | 2 | 0.12 |
| Tetracycline | 2 | 1 | 0.5 | <0.06 | 0.5 | 0.12 |
MIC measurements were done in the absence (none) or presence of 10 mM spermine (SpN).
