TABLE 1.
Effect of i.p. and p.o. T-1106 treatmenta on Syrian golden hamsters challenged with yellow fever virusb
| Treatment | Result forc:
|
|||||
|---|---|---|---|---|---|---|
| Toxicity controls
|
Infected and treated
|
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| No. alive/total | Mean wt changed (g) ± SDe | No. alive/total | MDDf ± SD | Mean serum ALT concn (IU/liter) ± SD | Mean wt changed (g) ± SD | |
| Expt 1 | ||||||
| T-1106 (100 mg/kg/day i.p.) | 3/3 | 5.3 ± 3.2 | 12/12** | >21 ± 0.0*** | 56 ± 5** | 7.1 ± 1.8** |
| Saline | 3/3 | 6.0 ± 2.0 | 5/12 | 9.0 ± 2.7 | 127 ± 99 | −0.9 ± 7.1 |
| Expt 2 | ||||||
| T-1106 | ||||||
| 32 mg/kg/day i.p. | 3/3 | 8.3 ± 4.0 | 10/10** | >21 ± 0.0*** | 65 ± 14*** | 5.2 ± 1.8** |
| 10 mg/kg/day i.p. | —g | — | 8/10 | 8.0 ± 1.4 | 174 ± 97 | −1.8 ± 7.7 |
| Saline | 3/3 | 5.3 ± 2.9 | 5/10 | 6.6 ± 0.5 | 230 ± 88 | −5.7 ± 9.0 |
| Normal control | 3/3 | 4.3 ± 2.1 | — | — | — | — |
| Expt 3 | ||||||
| T-1106 | ||||||
| 100 mg/kg/day p.o. | — | — | 10/10** | >21 ± 0.0*** | 56 ± 3.3*** | 6.3 ± 3.0*** |
| 32 mg/kg/day p.o. | — | — | 10/10** | >21 ± 0.0*** | 61 ± 4.8** | 4.4 ± 4.0** |
| Ribavirin (50 mg/kg/day i.p.) | — | — | 7/8** | 6.0 ± 0.0 | 120 ± 52 | 1.3 ± 4.0* |
| Saline | 3/3 | 4.0 ± 2.6 | 2/10 | 6.8 ± 1.0 | 168 ± 115 | −4.9 ± 6.9 |
| Normal control | 3/3 | 6.7 ± 4.0 | — | — | — | — |
a
Treated b.i.d. for 7 days beginning at −4 h.
b
Jimenez strain (10 CCID50/animal).
c
***, P ≤ 0.001, **, P ≤ 0.01, and *, P < 0.05, compared with saline-treated controls.
d
Difference between weights on 3 and 6 dpi.
e
Standard deviation (SD) was derived from a single experiment with the number of animals indicated in “No. alive/total” column.
f
MDD, mean day to death of mice dying prior to 21 dpi.
g
—, not applicable.