TABLE 2.

Effect of post-virus-exposure, i.p. T-1106 treatment on Syrian golden hamsters challenged with yellow fever virus^a

Treatment	Beginning of treatment schedule (b.i.d, 8 days)	Result forb:
		Toxicity controls		Infected and treated
		No. alive/total	Mean wt. changec (g) ± SDd	No. alive/total	MDDe ± SD	Mean serum ALT concn (IU/liter) ± SD	Mean wt changec (g) ± SD
Expt 3
T-1106 (100 mg/kg/day)	−4 h	3/3	8.0 ± 2.8	10/10***	>21 ± 0.0***	58 ± 2.6***	6.0 ± 4.0**
	1 dpi	—f	—	10/10***	>21 ± 0.0***	56 ± 5.7***	6.1 ± 5.4**
	2 dpi	—	—	10/10***	>21 ± 0.0***	57 ± 7.4***	6.3 ± 2.2***
	3 dpi	—	—	10/10***	>21 ± 0.0***	79 ± 23	2.9 ± 4.5**
Ribavirin (50 mg/kg/day)	−4 h	—	—	7/8**	6.0 ± 0.0	120 ± 52	1.3 ± 4.0*
Saline	−4 h	3/3	4.0 ± 2.6	2/10	6.8 ± 1.0	168 ± 115	−4.9 ± 6.9
Normal control	—	3/3	6.7 ± 4.0	—	—	—	—
Expt 4
T-1106 (100 mg/kg/day)	−4 h	—	—	10/10***	>21 ± 0.0***	55 ± 8.1**	7.2 ± 2.1**
	4 dpi	—	—	7/10**	6.0 ± 0.0	108 ± 42	−4.7 ± 8.8
	5 dpi	—	—	2/10	7.4 ± 0.9	205 ± 81	−6.9 ± 4.2
Ribavirin (50 mg/kg/day)	−4 h	—	—	9/10***	9.0 ± 0.0	98 ± 17**	4.1 ± 2.5**
Saline	−4 h	—	—	1/10	7.0 ± 1.2	183 ± 69	−5.2 ± 5.0
Normal control	—	3/3	7.7 ± 1.2	—	—	—	—

^aJimenez strain (10 CCID₅₀/animal).

^b***, P ≤ 0.001, **, P ≤ 0.01, and *, P < 0.05, compared with saline-treated controls.

^cDifference between weights on 3 and 6 dpi.

^dStandard deviation was derived from a single experiment with the number of animals indicated in “No. alive/total” column.

^eMDD, mean day to death of hamsters dying prior to 21 dpi.

^f—, not applicable.