FIG. 1.

Serum alters the IC₅₀ for glucan synthase from C. albicans by anidulafungin and caspofungin. Drug inhibition kinetics for glucan synthase from C. albicans strain 36082 were determined by monitoring the incorporation of [³H]uridine diphosphoglucose (CPM) as a function of anidulafungin (AFG) (A) or caspofungin (CAS) (B) concentration in the presence of increasing amounts of serum, as indicated. The calculated IC₅₀s are shown for each drug at a given serum level. All measurements were performed in triplicate.