FIG. 2.

Relative efficacies of caspofungin and micafungin in a murine candidiasis model. BALB/c mice (10 to 12 weeks; weight, 20 to 25 g) were infected by intravenous injection in the tail vein with 5 × 10⁵ cells of C. albicans strain 36082. After 24 h, they were treated daily for 14 days at 0.05, 0.1, or 1 mg/kg/day with either caspofungin (CAS) and anidulafungin (AFG) (A) or CAS and micafungin (MFG) (B). The mice were evaluated for fungal kidney burdens, expressed as log CFU. Negative sham (no drug [No tx control]) and positive ambisome (Amb) (4 mg/kg/day) controls are indicated. Panel C shows 90 and 99% effective doses (ED₉₀ and ED₉₉, respectively) obtained for the two drug trials (panels A and B). qd, once a day.