TABLE 2.

Effect of 50% serum on caspofungin and micafungin MECs^a of Aspergillus spp.

Aspergillus sp. (nb)	Result for drug
	Caspofungin			Anidulafungin			Micafungin
	MIC50		Fold change	MIC50		Fold change	MIC50		Fold change
	−Serum	+50% serum		−Serum	+50% serum		−Serum	+50% serum
A. fumigatus (10)	<0.25 (0.016-0.25)	1 (0.5-2.0)	11 (2-67)	0.0156 (0.016)	0.5 (0.25-2.0)	32 (32-128)	0.0156 (0.0156)	1 (0.5-2.0)	64 (33-133)
A. flavus (7)	0.03 (0.016-0.06)	0.5 (0.125-0.5)	8 (4-17)	0.0156 (0.016)	0.5 (0.125-1.0)	32 (16-64)	0.0156 (0.0156)	0.5 (0.5-2.0)	33 (17-33)
A. niger (8)	0.06 (0.06-0.25)	1.0 (0.5-1.0)	8 (4-17)	0.0156 (0.0156)	0.5 (0.25-0.5)	32 (16-32)	0.0156 (0.0156)	2 (0.5-2.0)	133 (33-133)
A. terreus (9)	0.125 (0.03-0.5)	0.5 (0.25-0.5)	4 (1-8)	0.0156 (0.0156)	0.25 (0.125-0.25)	16 (8-16)	0.0156 (0.0156)	0.5 (0.125-0.5)	32 (4-32)

^aMEC is defined as the lowest concentration of drug producing a macroscopically visible morphological change. For an explanation of values, see footnote a of Table 1.

^bn, no. of isolates.