TABLE 3.
IC50 for glucan synthase from Candida and Aspergillus
| Strain | EC50 of drug for glucan synthase (ng/ml)a
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caspofungin
|
Micafungin
|
Anidulafungin
|
||||||||||
| 0 | 10 | 20 | 50 | 0 | 10 | 20 | 50 | 0 | 10 | 20 | 50 | |
| A. fumigatus | ||||||||||||
| R21 | 1.6 | 2.7 | 3.6 | 10.3 | 3.7 | 6.2 | 10.3 | 23.2 | 0.75 | 1.9 | 3.1 | 11.9 |
| MF5668 | 1.1 | 1.0 | 3.2 | 4.8 | 2.2 | 3.2 | 3.3 | 7.6 | 0.29 | 5.5 | 6.9 | 28.1 |
| ATCC 13073 | 2.0 | 2.8 | 5.9 | 9.4 | 2.0 | 4.7 | 7.5 | 9.8 | 13.3 | 21.4 | 77.4 | |
| C. albicans | ||||||||||||
| ATCC 90028 | 0.3 | 1.3 | 2.1 | 6.3 | 18.0 | 28.4 | 50.1 | 90.2 | 1.00 | 4.72 | 18.6 | 24.7 |
| ATCC 36082 | 0.9 | 2.8 | 5.3 | 8.7 | 10.8 | 23.7 | 31.4 | 57.0 | 18.5 | 24.0 | 71.4 | |
| SC5314 | 14.7 | 27.0 | 36.9 | 80.5 | 26.9 | 32.6 | 50.6 | 89.7 | 17.1 | 15.3 | 74.7 | 89.0 |
a
EC50s (50% effective concentrations) of each drug are sorted by percentage of serum used (given below drug name).