TABLE 1.

Effects of tachyplesin III, colistin, and imipenem in a mouse model of P. aeruginosa-induced sepsis

Treatmenta (mg/kg)	Bacterial lethalityb				Blood culture result (24 h postchallenge)
	P. aeruginosa ATCC 27853		P. aeruginosa clinical isolate		No. positive/total no. of mice		CFU/ml (mean± SD) of:
	No. of mouse deaths/total no. of mice (%)	No. of mouse deaths within 24 h/total no. of mice	No. of mouse deaths/total no. of mice	No. of mouse deaths within 24 h/total no. of mice	P. aeruginosa ATCC 27853	P. aeruginosa clinical isolate	P. aeruginosa ATCC 27853	P. aeruginosa clinical isolate
Sodium chloride control	20/20 (100)	8/20	20/20 (100)	7/20	20/20	20/20	5.8 × 107 ± 0.8 × 107	7.9 × 107 ± 2.2 × 107
Tachyplesin III (1)	6/20c (30)	2/20	6/20c (30)	1/20	7/20c	10/20c	3.6 × 103 ± 0.6 × 103c	5.0 × 103 ± 0.9 × 103c
Colistin (1)	8/20c (40)	2/20	6/20c (30)	1/20	8/20c	13/20c	6.0 × 104 ± 1.7 × 104c	1.4 × 104 ± 8.6 × 103c
Imipenem (20)	6/20c (30)	1/20	16/20 (80)	4/20	6/20c	10/20	2.8 × 103 ± 0.4 × 103c	8.7 × 106 ± 2.9 × 106
Tachyplesin III (1) and imipenem (20)	1/20c,d (5)	0/20	2/20c,d (10)	0/20	1/20c,d	3/20c,d	1.1 × 101 ± 0.1 × 101c,d	1.6 × 101 ± 0.2 × 101c,d
Colistin (1) and imipenem (20)	2/20c,d (10)	0/20	3/20c,d (15)	1/20	2/20c,d	3/20c,d	4.6 × 101 ± 0.5 × 101c,d	5.2 × 101 ± 1.5 × 101c,d

^aTreatment was carried out immediately postchallenge.

^bMortality was monitored for 72 h following the challenge.

^cP < 0.05 (Fisher's test) or P < 0.05 (Bonferroni's test) versus the control group.

^dP < 0.05 (Fisher's test) or P < 0.05 (Bonferroni's test) versus the singly treated group.