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Sequence alignment of the amino acid sequences of β-lactamases SCO-1, CARB-5, TEM-1, SHV-1, and LAP-1. Dashes indicate amino acids which are lacking in the corresponding sequence. Critical residues that are involved in the extension of the substrate profile in TEM or SHV enzymes are in bold type. Gray-shaded amino acids represent conserved residues. The box VII is bracketed. β-Lactamases are numbered according to the Ambler classification (1).
