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Comparison of the drug resistance indexes by the MSF and [3H]HPX incorporation assays
| Test drug | Drug resistance indexa as determined by:
|
|
|---|---|---|
| MSF assay | [3H]HPX assay | |
| Chloroquine | 31.9 | 31.8 |
| Mefloquine | 0.5 | 0.5 |
| Quinine | 10.7 | 7.2 |
| Artemisinin | 0.8 | 0.7 |
| Doxycycline | 1.4 | 1.7 |
| Azithromycin | 0.2 | 1.5 |
| Pyrimethamine | 56.8 | 99.2 |
| Dapsone | 30.6 | 42.8 |
| Sulfadoxine | 305.4 | 69.6 |
Determined as The ratio of the W2 IC50 to the D6 IC50 at 72 h of incubation.
