Figure 1 .

: (A) Time course of mucosal permeability changes in untreated controls (+/+) (n=5), and elicited by L-NAME in +/+ (n=6), and mast cell deficient (W/W^V) mice (n=6). (B) L-NAME induced mucosal permeability changes expressed as a ratio of the maximum clearance to baseline value (10-20 minute clearance value) in the following groups: +/+, W/W^V, W/W^V pretreated with lodoxamide (Lod) (n=5), W/W^V pretreated with dexamethasone (Dex) (n=5), and W/W^V pretreated with aminoguanidine (AG) (n=6) and ICR mice (n=6). *p<0.05 relative to respective baseline value, †p<0.001 relative to L-NAME-treated +/+, *p<0.05, ‡p<0.001 relative to the peak clearance response of W/W^V.