Figure 1.

In a longitudinal aging study of PS/APP transgenic mice, Aβ load and distribution were compared in the cerebral cortex, at the level of the amygdala (except A) using antibody 4G8. Aβ deposition in mice younger than 3 months of age was initiated in the frontal cortex (A), but at this age, Aβ deposits were not visible elsewhere (B). By 7 months of age, Aβ deposition in the cerebral cortex and the hippocampus had increased extensively (C and D). After approximately 1 year of age, the total amyloid load remained more consistent (E and F). Scale bar, 1 mm.