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The activation of microglia in response to amyloid accumulation was compared in the frontal cortex of PS/APP mouse brains. A few CD11b-immunoreactive activated microglia were observed at 3 months of age (A), and the numbers increased with increasing amyloid burden and age (B–E). Activated microglia were observed surrounding Aβ deposits at all ages (F), although more generalized gliosis was also seen in older mice (E). Scale bars, 500 μm (in A for A–E) and 40 μm (F).
