Inhibitory effects of Axl-Fc on Thy1 GN. Effects of Axl-Fc treatment on glomerular cell proliferation (A) and expression of OX-7 (B). A representative glomerulus at day 8 of Thy1 GN is shown. a, control; b, treatment with Fc; c, treatment with Axl-Fc in A and B. A: PAS staining. B: Immunofluorescent staining for OX-7. Original magnification, ×200. C: The number of PCNA-positive cells per glomeruli. PCNA-positive cell numbers per glomerular cross-section are counted as described in Materials and Methods. Open bar, control rats (day 0); closed bar, nontreated Thy1 rats; double-hatched bar, Thy1 rats treated with Fc; shaded bar, Thy1 rats treated with Axl-Fc in C and D. *, P < 0.001 versus nontreated Thy1 rats. D: Urinary albumin excretion standardized by urinary creatinine of Thy1 rats at day 8. *, P < 0.001 versus nontreated Thy1 rats.