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. 2001 Apr;158(4):1423–1432. doi: 10.1016/S0002-9440(10)64093-X

Figure 4.

Figure 4.

Inhibitory effects of warfarin and Axl-Fc on expression of PDGF-B in Thy1 GN. A: Northern blot analysis of glomerular RNA of Thy1 rats at day 0, Thy1 rats without treatment (non treat), Thy1 rats treated with 0.5 mg/L warfarin (Wa), and Thy1 rats treated with Axl-Fc (Axl-Fc) at day 8. Shown are representative Northern blots for PDGF-B mRNA and corresponding GAPDH mRNA. B and C: Effects of warfarin and Axl-Fc treatment on glomerular expression of PDGF-B. B: Representative glomeruli of Thy1 rats at day 0 (a), day 8 (b), Thy1 GN treated with 0.5 mg/L of warfarin (c), Thy1 GN treated with Axl-Fc (d) at day 8. Immunofluorescent staining for PDGF-B. Original magnification, ×200. C: PDGF-B-staining score per glomerular cross-section is counted as described in Materials and Methods. Open bar, control rats (day 0); closed bar, nontreated Thy1 rats; dotted bar, Thy1 rats treated with warfarin (0.5 mg/L) (day 8); shaded bar, Thy1 rats treated with Axl-Fc (day 8). *, P < 0.001 versus nontreated Thy1 rats.