Table 3.
Summary of TCC-Associated Protein Data
| A. Detection of the 5 TCC-associated proteins in the study and control groups | ||||||||
|---|---|---|---|---|---|---|---|---|
| Number positive/number tested | P* | P** | ||||||
| Marker | Sensitivity % | Specificity N% | Specificity O% | Specificity All % | PPV% | NPV% | ||
| UBC1 | 47 (14/30) | 85 (5/34) | 87 (4/30) | 86 (9/64) | 61 | 76 | 0.01 < P < 0.025 | 0.01 < P < 0.025 |
| UBC2 | 53 (16/30) | 91 (3/34) | 70 (9/30) | 81 (12/64) | 57 | 79 | P < 0.001 | 0.1 < P < 0.25 |
| UBC3 | 70 (21/30) | 88 (4/34) | 70 (9/30) | 80 (13/64) | 62 | 85 | P < 0.001 | 0.001 < P < 0.005 |
| UBC4 | 43 (13/30) | 85 (5/34) | 87 (4/30) | 86 (9/64) | 59 | 76 | 0.01 < P < 0.025 | 0.01 < P < 0.025 |
| UBC5 | 63 (19/30) | 79 (7/34) | 60 (12/30) | 70 (19/64) | 50 | 80 | 0.001 < P < 0.005 | 0.1 < P < 0.25 |
| B. Frequency of the TCC-associated proteins according to age | ||
|---|---|---|
| Marker | Specificity N% (>50) | Specificity N% (<50) |
| UBC1 | 96 (1/22) | 67 (4/12) |
| UBC2 | 91 (2/22) | 92 (1/12) |
| UBC3 | 91 (2/22) | 83 (2/12) |
| UBC4 | 86 (3/22) | 83 (2/12) |
| UBC5 | 82 (4/22) | 75 (3/12) |
N, normal; O, other diseases; PPV, positive predictive value; NPV, negative predictive value. P*, P values from TCC and normal group comparison; P**, P values from TCC and other diseases group comparison.
>50, normal individuals older than 50 years old (range 50–71, mean 61.95); <50, normal individuals younger than 50 years old (range 23–49, mean 42.8).