Table 3.
Effect of in Vivo Cytokine Depletions on Chemokine mRNA Expression in Lungs with Two-Day, Type-1 (PPD) or Type-2 (SEA) Bead Granulomas
| Chemokine | mRNA expression (arbitrary units) | ||||
|---|---|---|---|---|---|
| Type 1 (PPD) | Type 2 (SEA) | ||||
| IgG | Anti-IFN-γ | Anti-TNF-α | IgG | Anti-IFN-γ | |
| KC | 97 ± 3 | 83 ± 14 | 64 ± 1* | 55 ± 30 | 66 ± 32 |
| LIX | 96 ± 1 | 98 ± 2 | 99 ± 1 | N.D. | N.D. |
| MIP-2 | 65 ± 34 | 65 ± 15 | 71 ± 2 | N.D. | N.D. |
| MIG | 90 ± 13 | 14 ± 6* | 41 ± 7* | 98 ± 2 | 40 ± 17* |
| IP-10 | 95 ± 7 | 80 ± 12 | 63 ± 6* | 73 ± 18 | 76 ± 23 |
| Lymphotactin | 93 ± 7 | 86 ± 12 | 65 ± 1* | 62 ± 25 | 46 ± 11 |
| MIP-1α | 95 ± 4 | 85 ± 13 | 59 ± 4* | 77 ± 21 | 57 ± 13 |
| LARC | 72 ± 19 | 83 ± 14 | 67 ± 1 | 69 ± 13 | 77 ± 21 |
| MCP-1 | 86 ± 4 | 84 ± 14 | 66 ± 1* | 92 ± 6 | 75 ± 16 |
| MCP-5 | 70 ± 40 | 70 ± 10 | 85 ± 21 | 78 ± 22 | 63 ± 34 |
| MCP-2 | N.D. | N.D. | N.D. | 70 ± 9 | 68 ± 28 |
| MCP-3 | N.D. | N.D. | N.D. | 86 ± 8 | 87 ± 14 |
| Eotaxin | N.D. | N.D. | N.D. | 73 ± 25 | 66 ± 10 |
| TARC | N.D. | N.D. | N.D. | 88 ± 8 | 89 ± 13 |
Values represent means ± SD derived from analysis of three separate lungs.
*P < 0.05.
N.D. = not done.