Table 1.

TIMP-1 Expression and the Tumorigenicity of Burkitt’s Lymphomas

	BL cell line
		AG876	PA686	JD38	ST482
TIMP-1 expression*	++++	++++	−	−
Epstein-Barr virus†	III	III	−	I
No. of animals with tumor (% with tumor)	24 (80%)	10 (70%)	17 (57%)	10 (60%)
Necrosis	19 (79%)	3 (43%)	0	0

*TIMP-1 expression analyzed by enzyme-linked immunosorbent assay and reverse zymography, as previously reported. 26

^†Latency of viral infection is shown in the EBV⁺ Burkitt’s lymphoma cell lines, as previously reported. 26