Figure 3.

Molecular analyses of various grades of PanIN. A: Frequencies of allelic loss at chromosomal regions 9p, 17p, and 18q together with frequencies of nuclear p53 expression and lack of Dpc4 protein expression. B: Accumulation of genetic alterations. The number of alterations refers to the number of allelic losses at three chromosomal regions (9p, 17p, and 18q) in those lesions that were informative for at least one marker at each of the three loci. PanIN-2/L, PanIN-2 lesion with low-grade dysplasia; PanIN-2/m, PanIN-2 lesion with moderate-grade dysplasia.