Table 2.
Genes Overexpressed in Chromophobe RCC/Oncocytomas Compared to Conventional RCCs
| Name | Genbank no. | Locus |
|---|---|---|
| 3-Oxoacid CoA transferase | U62961 | 5p13 |
| Adenine nucleotide translocator 2 | AW160902 | Xq24-q26 |
| Adenine nucleotide translocator 3 | J03592 | Xp22.32 Yp |
| Aspartate aminotransferase 1 | NM_002079 | 10q24.1-q25.1 |
| Carbonic anhydrase II | NM_000067 | 8q22 |
| Carbonic anhydrase XII | NM_001218 | 15q22 |
| CDC-like kinase 2 | AF023268 | 1q21 |
| Chloride channel Kb | Z30644 | 1p36 |
| Creatine/kinase 2, mitochondrial | J05401 | 5q13.3 |
| Cytochrome c oxidase subunit IV | NM_001861 | 16q24.1 |
| Cytochrome c oxidase subunit VIIb | Z14244 | X |
| Defensin, β 1 | U50931 | 8p23.2-p23.1 |
| Desmoglein 2 | NM_001943 | 18q12.1 |
| Desmoplakin | J05211 | 6p24 |
| Dihydrolipoamide dehydrogenase | U03620 | 7q31-q32 |
| EGF domain-containing extracellular matrix protein 1 | U03877 | 2p16 |
| EGF receptor pathway substrate 8 | AI679737 | 12q23-q24 |
| Epidermal growth facto | NM_001963 | 4q25 |
| EST (GenBank no. AA034414) | AA034414 | 12 |
| EST (GenBank no. AA284067) | AA284067 | Unmapped |
| EST (GenBank no. AA595322) | AA595322 | 15 |
| EST (GenBank no. AI090186) | AI090186 | 3 |
| EST (GenBank no. AI816358) | A1816358 | 7 |
| EST (Chloride channel Kb homolog) (GenBank no. AI311009) | AI311009 | 1p36 |
| EST/KIAA0439 (GenBank no. AB007899) | AB007899 | 18 |
| EST/KIAA0517 (GenBank no. AB011089) | AB011089 | 4 |
| Galectin 3 | AB006780 | 14q21-q22 |
| H+ Transporting ATPase (lysosomal vacuolar proton pump, β 1) | M25809 | 2cen-q13 |
| H+ Transporting ATP synthase (mitochondrial F0 complex, C 3) | AA479643 | 2 |
| H+ Transporting ATP synthase (mitochondrial F1 complex, α 1) | AW161540 | 18q12-q21 |
| Hydroxysteroid (11-beta) dehydrogenase 2 | U26726 | 16q22 |
| Isocitrate dehydrogenase 2 (NADP+), mitochondrial | X69433 | 15q26.1 |
| LIM/Senescent cell antigen-like domains 1 | NM_004987 | 2 |
| Mal, T-cell differentiation protein | NM_002371 | 2cen-q13 |
| NADH-CoQ reductase | X61100 | 2q33-q34 |
| NADH dehydrogenase (Ubiquinone) 1 α | AA813106 | Xq24 |
| Nicotinamide nucleotide transhydrogenase | Z5O101 | 5p13.1–5cen |
| Parvalbumin | AI022812 | 22q13.1 |
| Plastin 3 (T isoform) | M22299 | X |
| Propionyl CoA carboxylase α | NM_000282 | 13q32 |
| Ribosomal protein L17 | X53777 | 18q |
| Sialyltransferase 1 | AF007133 | 3q27-q28 |
| Single minded (drosophila) homologue 2 | U80456 | 21q22.2 |
| Syntaxin 3A | U32315 | 11 |
| TB1, human | AA723646 | 5 |
| Tetraspan 5 | AF065389 | 4 |
| Thioredoxin homologue | U60873 | 18 |
| Ubiquinol-cytochrome c reductase hinge | AA568387 | 1 |
The microarray data for these genes, including absolute differential expression levels in each of the seven tumors analyzed, are presented as Supplemental Data at www.amjpathol.org. The 43 genes in boldface make up the largest Quality Threshold cluster (Figure 2A) ▶ .