Table 1.

Characterization of MNA Neuroblastoma Tumors Identified by FISH to Exhibit Micronuclei Containing Amplified MYCN Sequences

NB number	Tissue sample	Age	Stage	Survival	Genetic aberrations
					Del 1p	MYCN Copy number per haploid genome	17q over- represent	Micronuclei per 100 nuclei
NB1	Bone marrow	19 mo	IV	12 months DOD	+	110	+	3
NB2	Primary tumor	5 years	IV	20 months alive	+	35	+	3
NB3	Primary tumor	2 years	IV	18 months DOD	+	298	+	5
NB4	Primary tumor	3 years	IV	19 months alive	+	ND	−	6
NB5	Primary tumor	28 months	IIIb/IV	5 months alive	+	ND	−	2
NB6	Primary tumor	8 months	IV	3 months alive	+	79	+	20
NB7	Primary tumor	4 years	IV	3 months alive	+	50	+	1
NB8	Primary tumor	2.5 years	IV	1 month alive	+	60	+	10

NB7–8 micronuclei were analysed only on imprinted slides, NB1–6 on cytogenetic slides.

ND, Not done; DOD, dead of disease.