Figure 7.

Effect of AT₁ and AT₂ antagonists on the glomeruli and tubulointerstitial areas of AngII-infused rats. ▶ shows a representative Southwestern experiment of an animal from each group: control (A and E), AngII-infusion (B and F), treatment with losartan (C and G), or with PD123319 (D and H). Both treatments showed a partial diminution in NF-κB staining in the glomeruli. Treatment with losartan only diminished NF-κB staining in tubular cells (G), whereas AT₂ blockade markedly diminished NF-κB-positive infiltrating interstitial cells (H). I: Semiquantitative score of NF-κB staining in glomeruli, infiltrating, and tubular cells. Results are expressed as means ± SEM of four to eight animals per group. *, P < 0.05 versus control; ^#, P < 0.05 versus AngII-infusion.