Table 2.
Genetic Aberrations in Preneoplastic Lesions of the Gastric Cardia
| Patient | Precursor | Aberrations | |
|---|---|---|---|
| 1 | HGD | loss: | 2q21-q22, 4p14-pter, 5p13-pter, 5q12-q33, 9p13-pter, 11q21-qter, 12q21 |
| gain: | 6p11.2-p21.3, 7q32-q34, 8q23, 19p13.1-pter, 19q13.1-q13.2 | ||
| 2 | LGD | loss: | n.a. |
| gain: | 17q21-qter | ||
| 3 | MET | loss: | 18q12-q21 |
| gain: | X | ||
| 4 | HGD | loss: | 1p21-p31, 1q23-qter, 2p12-pter, 2q13-q31, 3p13-pter, 4, 9p13-pter, 18, Y |
| gain: | 6p11.2-p22, 6q12-q15, 7q11.2-q22, 13q12-q22, 17q11.2-q21 (HLA 17q12-q21), Xq12-qter | ||
| 5 | HGD | loss: | 12, 18q12-qter, 19, 21q11.2-qter, 22 |
| gain: | 8q22-qter, 13, 20 | ||
| 6 | HGD | loss: | 2p23-pter, 5q12-qter, 9p13-pter, 9q21-q32, 15q11.2-q24, 17p12, 18q11.2-qter, 21, 22, Y |
| gain: | 1q32-qter, 5p14-pter, 7p11.2-pter, 7q11.2-q22 (HLA 7q21), 8 (HLA 8p22-q23), 12p11.2-p12, 20 | ||
| 7 | HGD | loss: | 1p13-pter, 1q41-q42, 2q31-qter, 3, 4, 5q12-qter, 8p21-pter, 10q22-qter, 14q13-qter, 16q13-qter, 18q12-qter, 20p11.2-p12, 21, Y |
| gain: | 5p12-pter, 6p11.2-p23, 6q12-q24, 7p11.2-pter, 7q11.2, 8q11.2-qter, 9p23, 9q13-q21, 13, 17q11.2-q24 (HLA 17q12-q21), 20q11.2-qter | ||
| 8 | MET | loss: | n.a. |
| gain: | n.a. | ||
| 9 | MET | loss: | n.a. |
| gain: | n.a. | ||
| 10 | MET | loss: | 19p13.2-pter |
| gain: | n.a. | ||
Alterations shared with the concurrent invasive cancer are printed in bold.
MET, metaplasia; LGD, low-grade dysplasia; HGD, high-grade dysplasia; HLA, high-level amplification; n.a., no aberrations.