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Fractionation of brain homogenates of PDAPP mouse brains. Brains of PDAPP mice aged 1.6 to 12.3 months were fractionated by sucrose density gradient centrifugation. Each fraction was spun down and the resulting pellet was extracted with guanidine hydrochloride. The extract was subjected to ELISA. Open and filled bars represent the levels of Aβ40 and Aβ42, respectively. The figures at the right in the last three columns indicate levels of Aβ42 (pmol/g).
