Table 1.
Cytokine Protein Concentrations in Splenocyte Cultures from MHV-68-Infected Mice
Day | IFN-γR+/+ | IFN-γR−/− | |
---|---|---|---|
IFN-γ | 10 | 3860 (3931) | 12992 (±6060) |
14 | 345 (465) | 32075 (±4821)* | |
TNF-α | 10 | 276 (125) | 273 (±82) |
14 | 187 (57) | 536 (±159)* |
Protein levels (pg/ml) were measured in supernatants of splenocytes cultured in vitro from MHV-68-infected mice. Note that in contrast to day 10, the levels of both cytokines were significantly elevated on day 14 in IFN-γR−/− mice.
* Statistically elevated in IFN-γR−/− mice; P < 0.05. Numbers represent mean ± SD (n = 4).