rhTRAIL induces apoptosis in human macrophage infected with different HIV-1 viral strains. A, Human MDM were infected with HIVBAL, HIVDJV, and HIV89.6 for 3 days, then incubated with or without TRAIL (50 ng/ml) for 24 h. Apoptosis was determined by DNA fragmentation apoptosis ELISA.*, p < 0.05 compared with control. #, p < 0.05 compared with rhTRAIL-treated uninfected MDM. ##, p < 0.01 compared with rhTRAIL-treated uninfected MDM. B, The infection levels of different HIV-1 strains were monitored by RT activity. **, p < 0.01 compared with control. Results shown are representative experiments performed with three different donors.