FIGURE 1.
Mean (±SD) RA in the choroid/RPE of form-deprived eyes relative to the fellow untreated control eyes are replotted from three earlier studies. Chick data are replotted from Mertz and Wallman.43 Marmoset data are from Mertz et al. (IOVS 2001;42:ARVO Abstract 56). Guinea pig data are replotted from McFadden et al.49 In all three studies, the RA in the form-deprived eyes was significantly different from the controls and the effect in chick is opposite to that in marmosets or guinea pigs. The rate of RA synthesis (converted to picomoles per hour) was measured in the studies of chicks and marmosets. RA concentration (measured as micrograms per gram wet weight) was measured in the study using guinea pigs.