. Author manuscript; available in PMC: 2008 Apr 1.

Published in final edited form as: Endocrinology. 2007 Jan 18;148(4):1590–1597. doi: 10.1210/en.2006-1170

Table 1.

Effects of every day (ED) or every other day (EOD) administration of vehicle solution, GH or PEG-T3C for 9 d on body weight gain and tibial epiphyses width in HYPOX rats.

Compound	Dose and Frequency ^a	Cumulative Body Weight Gain (g) ^b	Tibial Epiphyses Width (μm) ^b
Vehicle	ED	-1.0 ± 0.7	206.8 ± 9.2
GH	10 μ g ED	11.2 ± 1.0 ^c	348.8 ± 8.6 ^c
PEG-T3C	10 μ g ED	14.3 ± 0.8 ^c,^e	333.0 ± 9.8 ^c
Vehicle	EOD	0.6 ± 1.0	204.4 ± 8.6
GH	10 μ g EOD	8.6 ± 1.1 ^d,^g	298.8 ± 10.1 ^d
PEG-T3C	10 μ g EOD	15.4 ± 0.7 ^d, ^e, ^f	357.2 ± 7.7 ^d, ^f
PEG-T3C	2 μ g EOD	5.6 ± 0.5 ^d, ^e, ^g	274.8 ± 9.0 ^d, ^e, ^f
PEG-T3C	0.4 μ g EOD	-0.2 ± 0.7 ^e, ^f, ^g	225.2 ± 10.0 ^d, ^e, ^f, ^g,

ED rats were dosed on d 1-9. EOD rats were dosed on d 1, 3, 5, 7 and 9. Rats were sacrificed on d 10. The PEG-T3C doses exclude the contribution of PEG to the mass of PEG-T3C.

Means ± SE for 5 rats/group, except for the PEG-T3C ED group, which contained 4 rats. Body weights were measured over 10 d.

p < 0.05 vs ED vehicle

p < 0.05 vs EOD vehicle

p < 0.05 vs ED GH

p < 0.05 vs EOD GH

p < 0.05 vs ED PEG-T3C