. Author manuscript; available in PMC: 2008 Apr 1.

Published in final edited form as: Endocrinology. 2007 Jan 18;148(4):1590–1597. doi: 10.1210/en.2006-1170

Table 2.

Effects of every day (ED) or every third day (ETD) administration of vehicle solution, GH or PEG-T3C for 9 d on body weight gain and tibial epiphyses width in HYPOX rats

Compound	Dose and Frequency ^a	Cumulative Body Weight Gain (g)^b	Tibial Epiphyses Width (μm)^b
Vehicle	ED	0.8 ± 0.7	223 ± 15.1
GH	30 μ g ED	21.3 ± 1.4^c	408.4 ± 14.2^c
GH	10 μ g ED	16.2 ± 1.2 ^c,^g	399.6 ± 15.6 ^c
PEG-T3C	10 μ g ED	18.6 ± 2.2 ^c	384.4 ± 13.0 ^c
Vehicle	ETD	1.5 ± 1.4	231.6 ± 17.4
GH	30 μ g ETD	6.8 ± 1.4 ^d, ^g, ^h, ⁱ	315.2 ± 15.6 ^d, ^g, ^h, ⁱ
GH	10 μ g ETD	8.0 ± 1.6 ^d, ^g, ^h, ,ⁱ	284.0 ± 6.9 ^d, ^g, ^h, ⁱ
PEG-T3C	30 μ gETD	17.5 ± 1.2 ^d, ^e, ^f	428.4 ± 18.3 ^d, ^e, ^f
PEG-T3C	10 μ g ETD	12.3 ± 0.8 ^d, ^e, ^f, ^g, ^h	329.2 ± 15.6 ^d, ^f, ^h
PEG-T3C	2 μ g ETD	8.0 ± 1.4 ^d, ^g, ^h, ⁱ	263.2 ± 7.1 ^e, ^g, ^h, ⁱ

ED rats were dosed on d 1-9. ETD rats were dosed on d 1, 4 and 7. Rats were sacrificed on d 10. The PEG-T3C doses exclude the contribution of PEG to the mass of PEG-T3C.

means ± SE for 5 rats/group. Body weights were measured over 10 d.

p < 0.05 vs ED vehicle

p < 0.05 vs ETD vehicle

p < 0.05 vs ETD GH 30μg

p < 0.05 vs ETD GH 10μg

p < 0.05 vs ED GH 30μg

p < 0.05 vs ED GH 10μg

ⁱ

p < 0.05 vs ED PEG-T3C