Table 2.

Biological process categories overrepresented in each MG subgroup^a

	MH		ML		SN
Up-regulated genes
Immune response	32	***	34	**	28	NS
Ag presentation (MHC class II)	5	***	4	*	5	**
Response to stress	19	***	30	NS	20	NS
Response to wounding	11	***			8	NS
Inflammatory response	8	**			6	NS
Transcription regulator activity	15	NS	39	*	41	*
RNA Pol II transcription factor activity	7	*	13	*	11	NS
RNA metabolism	4	NS	15	*	11	NS
Intracellular protein transport	4	NS	18	*	11	NS
Protein folding			9	*
Cell growth			8	*	4	NS
Muscle development					10	**
Down-regulated genes
Cell proliferation	27	**	28	NS	30	NS
Nucleic acid metabolism			55	*
Response to stress			25	*
Cell-cell signaling				NS	25	*
Synaptic transmission					13	*
Protein kinase cascade					11	*

^aFor the up- and down-regulated genes extracted with SAM, the biological process categories significantly overrepresented compared with the entire array were searched in MH, ML, and SN patients using the Expression Analysis Systematic Explorer software (EASE) on the DAVID internet site. In each MG subgroup, categories with at least three genes and with an EASE score <0.05 are listed in this table. The numbers correspond to the numbers of up- and down-regulated genes in MH, ML, or SN patients. Asterisks indicate the significance of the EASE score:

^*p < 0.001;

^**p < 0.01;

^***p < 0.05;