Table 1.
Selected age-regulated genes of different functional categories. Down-regulated genes indicated with ↓, and up-regulated genes with ↑.
| Function/Gene Title | Gene | Fold Change |
|---|---|---|
| Lymphoid Lineage Specification/Function | ||
| Interleukin 7 receptor | IL7r | ↓ 13.7 |
| FMS-like tyrosine kinase 3 | Flt3 | ↓ 3.0 |
| c-srk tyrosine kinase | Csk | ↓ 1.6 |
| Phosphoinositide-3-kinase adaptor protein 1 | Pik3ap1/BCAP | ↓ 2.3 |
| Tumor necrosis factor receptor superfamily 13c | Tnfrsf13c/Baff | ↓ 3.3 |
| B-cell leukemia/lymphoma 11B | Bcl11b | ↓ 12.9 |
| SRY-box containing gene 4 | Sox4 | ↓ 2.1 |
| Myeloid Lineage Specification/Function | ||
| Friend leukemia integration site 1 | Fli-1 | ↑ 2.6 |
| CCAAT/enhancer binding protein beta | Cebpb | ↑ 1.9 |
| CCAAT/enhancer binding protein delta | Cebpd | ↑ 5.1 |
| Oncostatin M receptor | Osmr | ↑ 6.9 |
| Homeo box B6 | Hoxb6 | ↑ 2.7 |
| Promyelocytic leukemia | Pml | ↑ 5.1 |
| Runt related transcription factor 1 | AML1/Runx1 | ↑ 1.6 |
| CBFA2T1 identified gene homolog | ETO/Cbfa2t1h | ↑ 1.8 |
| Fibroblast growth factor receptor 1 | Fgfr1 | ↑ 2.0 |
| Myeloid Leukemia | ||
| Promyelocytic leukemia | Pml | ↑ 5.1 |
| Runt related transcription factor 1 | Runx1/AML1 | ↑ 1.6 |
| CBFA2T1 identified gene homolog | Cbfa2t1h/ETO | ↑ 1.8 |
| Fibroblast growth factor receptor 1 | Fgfr1 | ↑ 2.0 |
| Fibroblast growth factor receptor 3 | Fgfr3 | ↑ 2.0 |
| FGFR1 Oncogene partner 2 | Fgfr1op2 | ↑ 1.7 |
| Rho guanine nucleotide exchange factor | Arhgef12 | ↑ 2.0 |
| NCK interacting protein with SH# domain | Nckipsd | ↑ 2.7 |
| Epigenetic Regulation/Chromatin Remodeling | ||
| Enhancer of zeste homolog 2 | Ezh2 | ↓ 1.7 |
| High mobility group AT-hook 1 | Hmga1 | ↓ 3.5 |
| Special AT-rich sequence binding protein 1 | Sat1b | ↓ 2.7 |
| SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 | Smarca2/Brm | ↑ 2.6 |