Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Inhibition of mouse and human sEH by mono-amino acid derivatives of n-(3-adamantyl-ureido)-alkanoic acid
| R | Mouse sEH n = 3 IC50a (μM) | Human sEH n = 5 IC50a (μM) |
|---|---|---|
| OH | >100 | >100 |
| OCH3 | 0.10 | 1.8 |
| Alanine | >100 | >100 |
| Arginine | 16 | >100 |
| Aspartate | >100 | >100 |
| Glutamate | >100 | >100 |
| Glycine | >100 | >100 |
| Histidine | 0.05 | >100 |
| Isoleucine | 1.3 | >100 |
| Leucine | 15 | >100 |
| Methionine | 4.8 | >100 |
| Phenylalanine | 0.8 | 2.7 |
| Proline | 82 | >100 |
| Serine | 47 | >100 |
| Threonine | 33 | >100 |
| Tryptophan | 8.4 | 41 |
| Tyrosine | 18 | 80 |
| Valine | 30 | 55 |
