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Inhibition of human sEH by mono-amino acid derivatives of 1
| R | IC50a (μM) |
|---|---|
| OH (1) | 1.0 |
| Alanine | 0.26 |
| Arginine | 2.1 |
| Aspartate | >100 |
| Glutamate | >100 |
| Glycine | 1.5 |
| Histidine | 5.5 |
| Isoleucine | 0.13 |
| Leucine | 0.88 |
| Methionine | 0.87 |
| Phenylalanine | 0.10 |
| Proline | 0.10 |
| Serine | 2.4 |
| Threonine | 1.3 |
| Tryptophan | 0.10 |
| Tyrosine | 0.23 |
| Valine | 0.10 |
