. Author manuscript; available in PMC: 2007 Jun 15.

Published in final edited form as: Bioorg Med Chem Lett. 2006 Oct 15;16(20):5439–5444. doi: 10.1016/j.bmcl.2006.07.073

Table 4.

Pharmacokinetic profile data for compounds 2 and AUDA as obtained via oral dosing in a canine model

	Time (min)	2	AUDA
Plasma concentration (nM)	0	0.00	0.00
	15	0.62	6.97
	30	0.82	20.43
	60	0.33	30.69
	120	0.00	26.31
	180	0.00	13.39
	240	0.00	6.12
	300	0.00	1.61
	360	0.00	1.17
	480	0.00	0.86
	1440	0.00	0.00
AUC^a (×10⁴ nM min)		<0.01	0.31

Area under the curve, estimated from a plot of inhibitor plasma concentration (nM) versus time (minutes) following an oral dose of 0.3 mg/Kg of the indicated compounds in 6 mL of tristerate.¹⁷