Table 1.
Physiological Parameters in Uninephrectomy (UNX), Deoxycorticosterone Acetate (DOCA)-Salt, and N-adamantyl-N′-dodecylurea (ADU)-Treated Rats
| UNX | UNX+ADU | DOCA-salt (2 wk) | DOCA-salt (4 wk) | DOCA-salt +ADU | |
|---|---|---|---|---|---|
| Initial body weight (g) | 321 ± 4 (n = 8) | 313 ± 6 (n = 8) | 314 ± 2 (n = 12) | 321 ± 5 (n = 10) | 308 ± 3 (n = 13) |
| Final body weight(g) | 380 ± 7 (n = 8) | 383 ± 7 (n = 8) | 332 ± 7a (n = 12) | 335 ± 6a (n = 10) | 314 ± 6a (n = 13) |
| LV + septum weight relative to body weight (mg/g) | 1.99 ± 0.04 (n = 8) | 1.85 ± 0.04 (n = 8) | 2.27 ± 0.05a,b (n = 12) | 2.71 ± 0.08a (n = 10) | 2.45 ± 0.06a,b (n = 13) |
| LV + septum weight relative to tibial length (g/m) | 18.3 ± 0.5 (n = 8) | 17.1 ± 0.2 (n = 8) | 19.3 ± 0.8b (n = 12) | 22.6 ± 0.7a (n = 11) | 18.9 ± 0.4 (n = 13) |
| Kidney weight relative to body weight (mg/g) | 5.20 ± 0.28 (n = 8) | 5.40 ± 0.15 (n = 8) | 7.51 ± 0.25a,b (n = 12) | 8.85 ± 0.39a (n = 11) | 9.46 ± 0.31a (n = 13) |
| Plasma Na+ concentration (mM) | 133.6 ± 1.6 (n = 8) | 134.2 ± 1.1 (n = 10) | 136.5 ± 0.3 (n = 10) | 138.2 ± 0.7 (n = 10) | 134.6 ± 1.6 (n = 10) |
| Plasma K+ concentration (mM) | 4.0 ± 0.4 (n = 8) | 3.7 ± 0.4 (n = 10) | 2.2 ± 0.2a (n = 10) | 2.3 ± 0.2a (n = 10) | 2.3 ± 0.2a (n = 10) |
| Inflammatory score | 0.67 ± 0.21 (n = 6) | 0.36 ± 0.18 (n = 7 | 2.36 ± 0.50a (n = 7) | 3.08 ± 0.37a (n = 6) | 3.14 ± 0.24a (n = 7) |
| Interstitial fibrosis (%area) | 2.61 ± 0.24 (n = 6) | 2.70 ± 0.30 (n = 7 | 4.38 ± 0.35a (n = 6) | 5.41 ± 0.65a (n = 6) | 5.21 ± 0.21a (n = 7) |
| Perivascular Fibrosis (%area) | 22.5 ± 1.8 (n = 6) | 21.2 ± 1.1 (n = 7) | 27.1 ± 0.8a (n = 6) | 31.3 ± 1.7a (n = 6) | 29.5 ± 1.2a (n = 7) |
| Diastolic Stiffness Constant (k) | 22.5 ± 0.4 (n = 7) | 22.4 ± 0.3 (n = 7) | 22.1 ± 0.3 (n = 8) | 24.8 ± 0.6a (n = 12) | 25.9 ± 0.6a (n = 8) |
a
p < 0.05 compared to UNX.
b
p < 0.05 compared to DOCA-salt (4 wk).