Table 2.
Cardiac Electrophysiological Parameters in Uninephrectomy (UNX), Deoxycorticosterone Acetate (DOCA)-Salt, and N-Adamantyl-N′-Dodecylurea (ADU)-Treated Rats
| UNX | UNX+ADU | DOCA-salt (2 week) | DOCA-salt (4 week) | DOCA-salt +ADU | |
|---|---|---|---|---|---|
| Resting Membrane Potential (mV) | −76 ± 2 (n = 6) | −77 ± 2 (n = 7) | −68 ± 3 (n = 7) | −71 ± 1 (n = 10) | −74 ± 4 (n = 7) |
| Cardiac action potential Amplitude (mV) | 98 ± 4 (n = 6) | 93 ± 3 (n = 7) | 87 ± 2 (n = 7) | 92 ± 1 (n = 10) | 97 ± 4 (n = 7) |
| APD20 (ms) | 9.5 ± 0.7 (n = 6) | 10.3 ± 1.1 (n = 7) | 11.7 ± 1.1 (n = 7) | 14.5 ± 1.2a (n = 10) | 16.7 ± 1.8a (n = 7) |
| APD50 (ms) | 24.0 ± 1.5 (n = 6) | 24.5 ± 2.2 (n = 7) | 28.8 ± 2.2 (n = 7) | 37.3 ± 2.6a (n = 10) | 46.2 ± 5.5a (n = 7) |
| APD90 (ms) | 66.6 ± 3.1 (n = 6) | 65.7 ± 3.4 (n =7) | 86.0 ± 6.9 (n = 7) | 105.3 ± 2.9a (n = 10) | 109.4 ± 5.8a (n = 7) |
a
p < 0.05 compared to UNX.